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Eno River State Park is located in Durham and Orange counties, northwest of the city of Durham.
From Interstate 85 exit 173, take Cole Mill Road northwest away from Durham. After five miles, Cole Mill Road will end at the park's Fews Ford Access.
From Interstate 85 exit 170, take Hwy. 70 west to Pleasant Green Road. Turn right and follow Pleasant Green 2.2 miles, then turn left on Cole Mill Road. After one mile, Cole Mill Road will enter the park's Fews Ford Access.